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KMID : 0363620110320030044
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Journal of Korean Oriental Medicine
2011 Volume.32 No. 3 p.44 ~ p.49
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Overview of RCT for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
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Son Chang-Gue
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Abstract
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Objective: This study aimed to get information on the current status of therapies to date for non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH).
Methods: All randomized clinical controlled trial (RCT)-derived papers for NAFLD or NASH were reviewed via PubMed Database.
Results: 39 RCTs met the review criteria, of which 15 and 24 papers were for NAFLD and NASH, respectively. 83% of the papers were released since 2006, and 30 studies were conducted for western medicines, antioxidants and lifestyle intervention whereas nine trials were done using herbal medicine or acupuncture which showed positive outcome.
Conclusions: NAFLD and NASH are new epidemic disorders which can be a target of traditional Oriental medicine. This study will be helpful for the Oriental medicine-based strategies or therapeutic development for them.
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KEYWORD
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Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, randomized controlled trial, traditional Korean medicine, herbal drug
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